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CVS Pharmacy

Store ID: #5596

4627 NORTH MAIN STREET, COLUMBIA, SC 29203

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(803) 786-1106

Today's hours

  • Store & Photo: Open , closes at 9:00 PM
  • Pharmacy: Open , closes at 9:00 PM
  • Pharmacy closes for lunch from 1:30 PM to 2:00 PM

In-store services:

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Buy online for pickup

Search products available for pickup at this store.

Manage Prescriptions
Access orders, request refills, get drug resources and more.
Explore Photo
Personalized photos, mugs, cards and gifts.

Find 15+ vaccines, including COVID-19, RSV, shingles, and more. Schedule online or walk in.

Book a vaccination


Store hours

  1. Today - Open 8:00 AM to 9:00 PM
    Fri., Apr. 25
  2. Saturday 8:00 AM to 9:00 PM
    Apr. 26
  3. Sunday 9:00 AM to 7:00 PM
    Apr. 27
  4. Monday 8:00 AM to 9:00 PM
    Apr. 28
  5. Tuesday 8:00 AM to 9:00 PM
    Apr. 29
  6. Wednesday 8:00 AM to 9:00 PM
    Apr. 30
  7. Thursday 8:00 AM to 9:00 PM
    May. 1

Pharmacy hours

  1. Pharmacy closes for lunch from 1:30 PM to 2:00 PM
  2. Today - Open 9:00 AM to 9:00 PM
    Fri., Apr. 25
  3. Saturday 9:00 AM to 6:00 PM
    Apr. 26
  4. Sunday 10:00 AM to 6:00 PM
    Apr. 27
  5. Monday 9:00 AM to 9:00 PM
    Apr. 28
  6. Tuesday 9:00 AM to 9:00 PM
    Apr. 29
  7. Wednesday 9:00 AM to 9:00 PM
    Apr. 30
  8. Thursday 9:00 AM to 9:00 PM
    May. 1
Manage Prescriptions

Nearby stores

  1. 1.5 miles

    3595 Harden St
    Columbia, SC, 29203

    Get directions
    Store details
  2. 2.3 miles

    3700 Two Notch Road
    Columbia, SC, 29204

    Get directions
    Store details
  3. 3.4 miles

    900 Assembly St.
    Columbia, SC, 29201

    Get directions
    Store details
Search nearby stores

Discover our services at 4627 North Main Street

CVS Pharmacy

Pharmacy closes for lunch from 1:30 PM to 2:00 PM

Sinus care

Get sinus relief.

View sinus medications
Rx refill
Rx delivery
Prescription transfer
Drug info center
Rx rewards
Prescription savings
All CVS Pharmacy immunizations

Photo

Create photo cards, books, gifts, and canvas prints

Passport photos

Quick, convenient and government compliant.

Shop passport photos
Photo gifts
Photo printing
Film processing
Shop all photo

About this pharmacy & drug store

Does CVS at 4627 North Main Street Columbia, SC 29203 test for coronavirus (COVID-19)?

CVS Health is conducting coronavirus testing (COVID-19) at 4627 North Main Street Columbia, SC. Patients are required to schedule an appointment for in advance. Limited appointments are available to qualifying patients due to high demand. Test types vary by location and will be confirmed during the scheduling process. Patients must bring their insurance card and proof of identity*. Also, find for sale online and in-store.

*Insurance is not required at community testing locations.

Does CVS at 4627 North Main Street Columbia, SC 29203 offer flu shots?

are offered at the CVS Pharmacy at 4627 North Main Street Columbia, SC 29203.

Schedule your flu shot ahead of time so you can get in and out faster. Provide your insurance information and answer questions online ahead of time. Shop cold and flu and stay prepared this cold and flu season with immunity support products and more.

Pick up and drop off UPS® packages

Offering extra flexibility, convenience, and safety to all your packaging and shipment needs, our CVS store is now an active UPS Access Point. Drop-off and pick up your packages with UPS tracking available, so you can be sure it’s arrived. We’ll hold packages for up to 7 days, so you can pick them up on your schedule. For UPS package drop-offs, we accept pre-labeled, prepaid packages for 5 to 7 day ground and air delivery. UPS will collect all packages within 24 hours.

Find more UPS Access Point information for packages that may not qualify for shipment from our location.